ECE2013 Poster Presentations Thyroid cancer (64 abstracts)
The role of radioiodine SPECT/CT in differentiated thyroid cancer
Emese Mezosi 1 , Laszlo Bajnok 1 , Karoly Rucz 1 , Csaba Weninger 2 , Erzsebet Schmidt 3 , Zsuzsanna Szabo 3 , Sarolta Szekeres 3 & Katalin Zambo 3
11st Department of Internal Medicine, University of Pecs, Pecs, Hungary; 2Department of Radiology, University of Pecs, Pecs, Hungary; 3Department of Nuclear Medicine, University of Pecs, Pecs, Hungary.
Introduction: Beside remnant ablation and treatment of known metastases, radioiodine treatment of differentiated thyroid cancer is suitable for the discovery of unknown or suspected metastatic disease. In this study, the clinical utility of SPECT/CT, a hybrid imaging method was evaluated after radioiodine therapy.
Patients and methods: Between July 2007 and March 2012, 260 investigations were performed at 188 patients. Male:female ratio was 47:141. Every patient was evaluated by whole body scanning (5 cm/min), planar (100K) and SPECT/CT imaging (SPECT: two detectors, 50 s/frame, 64 frame; CT: low dose, 16-slice helical CT, 120 KeV, 50 mAs) 6 days after 1100–3700 MBq radioiodine treatment.
Results: Only remnant thyroid tissue was detected in 122 patients (47%). Absence of any radioiodine uptake plus a negative CT was found during 16 investigations (all were after repeated treatment). Pathological isotope accumulation was diagnosed with positive CT result in 96 cases (37%). Radioiodine uptake with suspected clinical significance without CT abnormality was found in 22 cases (8%). Radioiodine negative metastases were discovered during 21 investigations (8%). Lymph node, lung, bone and other metastases were diagnosed in 79, 41, 19 and 12 cases, respectively. Nonspecific radioiodine uptake was found during 23 investigations caused by gluteal hematoma, kidney cyst, inflamed ulcer of the lower extremity, foreign body in the neck, gingivitis, isotope contamination of the skin and body hair, etc. As a consequence of a positive SPECT/CT imaging, 19 patients were operated after radioiodine treatment, mostly by gamma-probe guided surgery.
Conclusion: The SPECT/CT hybrid imaging method after radioiodine treatment proved to be useful in the discovery and localization of metastatic disease, exclusion of artifacts, therapeutic setting and indication of surgery.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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