Endocrine Abstracts

Background: Hypogonadism in men is associated with low muscle mass and force. Although, androgen replacement is an effective therapy, it can have undesirable side effects. Identifying the androgen regulated molecular mechanisms that increase muscle mass and function could lead to the identification of novel muscle-specific therapeutic targets to improve the clinical outcomes of muscle wasting diseases. In this study, we examined in mice the effects of orchidectomy (after 1, 7 ...

Introduction: Hormonal therapy is part of an established treatment of gender identity disorder, however outcome data regarding mortality and morbidity are scant.Methods: A specialist center cross-sectional study in 193 transsexual women and 128 transsexual men (mean age 42.5 years) assessing physical health and incidence of possible treatment related adverse events compared to an age-matched female and male control group recruited from a population study...

Background: Cushing’s syndrome (CS) is considered to be more frequent among patients with metabolic syndrome. Previous studies have suggested to perform a routine screening for CS in obese patients; however, more recent reports only recommend a case-finding approach in patients with uncontrolled diabetes and hypertension, despite appropriate treatment.Objective: The aim of this study was to evaluate the prevalence of unsuspected CS in morbidly obese...

Using real-time PCR, we found that RDH12 is highly expressed in the skin of Macacafascicularis (mf). It has been known that RDH12 is a retinol dehydrogenase that catalyzes the reduction of retinal into retinol and play an important role in the visual cycle. Indeed, its deficiency is the cause of Leber’s congenital amaurosis 3, a genetic disorder characterized by retinal dystrophy affecting both rods and cones. Previously, we have shown that many of the members of the reti...

Introduction: Critical illness, and sepsis in particular, drives adipose tissue lipolysis up (with triglycerides (TG) being split to free fatty acids (FFA) and glycerol (GLYC)) to meet increased energy demands. Few studies have addressed lipolysis with tissue microdialysis (MD).Aim: To assess indexes of lipolysis in septic patients with and without shock.Subjects and methods: The study included 110 men and 73 women (mean age+<small...

Introduction: The UGT2B17 gene encodes a glucuronidase which is important for the urinary excretion of testosterone. Recent studies have shown that a common deletion polymorphism in UGT2B17 is strongly associated with significant lower levels of excreted urinary testosterone in men. The objective of this study was to investigate the association of the UGT2B17 gene polymorphism and the dosages of testosterone substitution in male patients with frank hypogonadism.<p class="a...

The ratio of the glucuronidated epitestosterone (E) and testosterone (T), used in doping tests, is currently under question. The key enzyme involved in E metabolism is UGT2B7 in contrast to T which is mainly metabolised by UGT2B17. Previous results demonstrated that at very high concentrations E acts as a competitive inhibitor to UGT2B17. Similarly, the literature reports competitive inhibition of UGTs by NSAIDS and phenolics that are not substrates of UGT2B17. The aim of this...

Introduction: The dependence on tobacco, diagnosis F 17, is an independent condition in the International classification of diseases and presents one of the most widespread addictions. Chronic smoking can cause impairment of fertility in both sexes. However, only a small number of studies were dedicated to the influence of smoking on levels of steroid hormones and their neuroactive metabolites. Neuroactive steroids modulate the effects of tobacco on central nervous system, and...

Introduction: Obesity epidemic has a considerable effect on the health of the population. Obesity is connected with infertility and hypogonadism. It is known that obese men have a low testosterone and higher estradiol level. The assumed mechanism would be increased testosterone aromatization in adipose tissue and a lower SHBG level, which means a decrease of overall testosterone. The aim of this study was to describe the changes of steroidogenesis with obese men.<p class="...