ECE2013 Poster Presentations Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) (127 abstracts)
Role of reversal of hypogonadism on the improvement of metabolic syndrome in male patients with hyperprolactinemia during chronic treatment with cabergoline
Mariano Galdiero , Renata S Auriemma , Fabio Lo Calzo , Pasquale Vitale , Claudia Pivonello , Federica Cariati , Ylenia Perone , Ciro Salzano , Annamaria Colao & Rosario Pivonello
Department of Clinical Medicine and Surgery ‘Federico II’ University, Naples, Italy.
Introduction: Hyperprolactinemia (HPRL) is associated with an impaired metabolic profile, particularly in patients with hypogonadism. This study aimed to: i) investigate the effects of short and long treatment with cabergoline (CAB) on the prevalence of metabolic syndrome (MS) and insulin sensitivity and ii) to evaluate the impact of gonadal function on metabolic changes, in male patients with HPRL.
Patients and methods: Nineteen patients (41±13.9 years) with HPRL entered the study. PRL, total testosterone, BMI, waist circumference, lipid and glucose profile and fasting insulin levels were assessed at diagnosis and after short (12 months) and long-term (60 months) treatment with CAB. NCEP-ATP III criteria were used.
Results: At baseline, the prevalence of hypogonadism was 73% while prevalence of MS was 52%: MS prevalence was higher in patients with (74%) than in those without (25%) hypogonadism. A significantly higher waist and BMI was found in hypogonadic than in normogonadic patients. CAB induced PRL normalization in 74 and 92% of patients after 12 and 60 months respectively. Hypogonadism was found in 42 and 10% after respectively 12 and 60 months, where MS significantly decreased to 10%. Serum triglycerides, total cholesterol, insulin levels, BMI and HOMA-IR were significantly reduced after 12 and 60 months whereas an increase of HDL was registered after 60-month follow-up. CAB dose and PRL changes correlated with the changes in BMI after long-term treatment. Testosterone levels negatively correlated with waist, insulin levels and HOMA-IR either at baseline and after treatment. Testosterone levels was the best predictor of HOMA-IR.
Conclusions: In conclusion, normal testosterone levels play an important role in the amelioration of MS of patients with HPRL by improving of insulin resistance.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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