Endocrine Abstracts

Aim: To find and study character of clinical disorders of children and adolescents (boys) with different disorders of puberty development.

Materials and methods: During April–May 2012 we examined 521 children and adolescents (boys) in Bukhara city and four Bukhara districts schools. 143 of them were underwent general clinical examination as well as biochemical and hormonal investigations (levels of LH, FSH, GH, testosterone, sex-steroid ass. globulin, prolactin, cortisol, TSH, T₄, etc.), roentgenologic examination (Turkish saddle CT and MRI and hand roentgenogram), clinical ultrasound of the thyroid and sex organs, anthropometric examination, having their sexual development stage by Tanner assessed. Mean age of boys was from 11.0 to 16 years.

Results: Examination of 521 boys allowed diagnosing a number of different disorders of puberty development in 143 boys (29.4%). By character of pathology the examinees were divided into three groups. The 1st group included 106 patients from 143 (74.1%) with delay of puberty, the 2nd group including 13 patients (9.09%) with retardation of puberty and growth, the 3rd group including 11 patients (7.7%) with gynecomastia (one of boys having obesity), the 4th group – five patients (3.5%) having micropenis+obesity, the 5th group – two patients (1.4%) having varicocele, the 6th group – 2 patients (1.4%) with anorchia, the 7th group – two patients (1.4%) having cryptorchidism, the 8th group – and one patient (0.6%) having precocious puberty.

Conclusions: i) Among disorders of puberty development in teenagers more frequent found delay of puberty (74.1%). ii) There are different disorders of puberty development was established: retardation of puberty and growth (9.0%), gynecomastia (7.7%), micropenis+obesity (3%), varicocele (1.4%), cryptorchidism (1.4), and precocious puberty (0.6%).