ECE2013 Poster Presentations Obesity (65 abstracts)
No long-term weight reduction after gastric banding (LAGB) in obese patients with craniopharyngioma involving hypothalamic structures: experiences from KRANIOPHARYNGEOM 2000
Anthe Sterkenburg 1, , Ursel Gebhardt 1 , Anika Hioffmann 1 , Jörn Maroske 3 , Ernst Hanisch 4 & Hermann Müller 1
1Department of Pediatrics, Klinikum Oldenburg, Oldenburg, Germany; 2University Hospital Groningen (UMCG), Groningen, The Netherlands; 3Department of Surgrey, Verbundklinikum Rothenburg o.d.Tauber, Rothenburg, Germany; 4Department of General, Visceral, and Endocrine Surgery, Asklepios Klinik, Langen, Germany.
Background: Craniopharyngiomas are embryogenic malformations which lead to eating disorders and morbid obesity due to hypothalamic involvement. The experience with laparoscopic adjustable gastric banding (LAGB) in obese craniopharyngioma patients is limited especially in regard to long-term effects and tolerability.
Patients and methods: We are reporting on four patients with childhood craniopharyngioma diagnosed at age 2, 13, 12, and 20 years.
Results: BMI–SDS at diagnosis was −0.9,+4.5,+4.7 and +0.23 S.D.. All patients developed morbid obesity (BMI–SDS: +10.87,+10.36,+11.4,+6.2) so that 11, 5, 9 and 3 years after diagnosis LAGB were performed. LAGB were well tolerated. During long-term follow-up, the nadir BMI–SDS (+6.9,+9.5,+7.8, +4.9) were reached 2.0, 0.5, 1.0, 0.8 years after LAGB. At last evaluation 9.1, 5.3, 7.1, 7.1 years after LAGB, the patients BMI (BMI–SDS at last evaluation: +10.2,+13.9,+10.2,+6.3) had increased again but remained at a constant level comparable with baseline BMI–SDS at the time of LABG. Quality of life was not decreased due to LAGB and tolerability was sufficient.
Conclusions: We conclude that LAGB is feasible and could have clinical relevant effects on long-term weight stabilization of obese craniopharyngioma patients with hypothalamic syndrome. However, a significant weight reduction was not achieved after LAGB in patients with childhood craniopharyngioma. Non-reversible bariatric procedures such as gastric bypass are not recommended for treatment of obese children and adolescents with craniopharyngioma due to ethical considerations.
Article tools
My recent searches
My recently viewed abstracts
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more