ECE2013 Poster Presentations Growth hormome IGF axis – basic (16 abstracts)
Sheehan’s syndrome females have a high incidence of cardiovascular morbidity and an increased prevalence of cardiovascular risk factors
Ines Slim 1 , Nadra Bhouri 1 , Houneida Zaghouane 3 , Molka Chadli 1 , Monia Zaouali 2 , Koussay Ach 1 , Amel Maaroufi 1 , Maha Kacem 1 , Chakib Kraiem 3 & Larbi Chaieb 1
1Department of Diabetes and Endocrinology, Farhat Hahed Univsity Hospital, Sousse, Tunisia; 2Department of Physiology, Ibn Jazzar Faculty of Medicine, University of Sousse, Sousse, Tunisia; 3Department of Radiology, Farhat Hached University Hospital, Sousse, Tunisia.
Introduction: While severe GH deficiency (GHD) is a well-established feature of Sheehan’s syndrome (SS), the effects of GH deficiency in these patients has not been extensively investigated. In the present studyh we evaluated the cardiovascular risk in patients with SS.
Methods: Twenty female with SS and well-treated with cortisone and thyroid hormones was included. Metabolic syndrome according to IDF-2005 criteria and insulin resistance estimated by HOMA-IR were investigated. GHD was searched based on Glucagon test. Common carotid intima-media thickness (IMT) was measured by B mode ultrasound. Cardiovascular risk was assessed by SCORE.
Results: The GHD was found in 95% of patients. Hypertension represents the most frequent history of cardiovascular disease. The mean BMI was at 28.10±6 kg/m2, 35% of patients were obese. The mean waist circumference was at 99.5±15 cm. Fasting glucose more than 5.5 mmol/l was present in 45% of subjects. A total cholesterol >5.2 mmol/l was observed in 65% of cases, an LDL-C >4.1 mmol/l in 35% of cases, an HDL-C <1 mmol/l in 15% and a triglyceride level >1.7 mmol/l in 60% of cases. Metabolic syndrome was present in 55% of cases. Forty percent of patients had insulin resistance. The IMT was not increased in all cases; the presence of atheromatous plaques was noted in one case. The IMT was positively correlated with diastolic blood pressure and LDL-C. Cardiovascular risk was moderate in 40% of cases and very high in 15% of cases. Patients with high cardiovascular risk had higher systolic blood pressure and fasting glucose.
Conclusion: These findings highlight the importance of closely cardiovascular and metabolic monitoring of patients with SS unsubstituted in GH and raise the question of the benefit of GH replacement in these patients.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more