ECE2013 Poster Presentations Female reproduction (47 abstracts)
PON1-108 TT and PON1-192 RR genotypes are more frequently encountered in Greek PCOS than non-PCOS women, and are associated with hyperandrogenemia
George Mastorakos 1 , George Paltoglou 1 , George Tavernarakis 1 , Panagiotis Christopoulos 1 , Margarita Vlassi 1 , Maria Gazouli 2 , Efthimios Deligeoroglou 1 & George Creatsas 1
12nd Department of Obstetrics and Gynaecology, Aretaieion University Hospital, Athens Medical School, Athens, Greece; 2Laboratory of Biology, University of Athens, School of Medicine University of Athens, Athens, Greece.
Objective: To investigate the frequencies of three paraoxonase (PON)1 polymorphisms in Greek polycystic ovary syndrome (PCOS) and non-PCOS women, and their genotypes in association with hyperandrogenemia and insulin resistance.
Design: Case–control genetic association study.
Patients: PCOS cases (NIH criteria) and 112 controls.
Main outcome measure: Genotyping of the c.−108C>T (PON1-108), the c.163T>A (PON1-55) and the c.575A>G (PON1-192) polymorphisms and measurement of baseline androgen and insulin resistance profile.
Results: The PON1-108 TT and PON1-192 RR genotypes were more frequently encountered in the PCOS than in the control group. The PON1-192 R allele frequency was greater in the PCOS than in the control group. Comparing the PCOS and the control groups, statistical significances favored a recessive and a dominant genetic model, respectively, for the single PON1-108 T and PON1-192 R alleles. Free androgen index (FAI) levels were higher in patients with PON1-108 TT, while testosterone, FAI and dehydroepiandrosterone sulfate (DHEAS) levels were higher in patients with PON1-192 RR than in patients with the wild or the heterozygous genotype.
Conclusions: The decreased PON1 activity-associated PON1-108 TT and the PON1-192 RR genotypes are more frequently found in Greek PCOS women and are associated with hyperandrogenemia. Hyperandrogenemia must depend also on other genetic factors because the same genotypes were not associated with hyperandrogenemia in the control group. Through identification of the involved polymorphisms women with PCOS could potentially have a better therapeutic screening.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more