ECE2013 Poster Presentations Female reproduction (47 abstracts)
Relation of adiponectin and leptin to antropometric and metabolic parameteres in women with polycystic ovaries syndrome
Tamara Bogavac 1 , Djuro Macut 1 , Ivana Bozic Antic 1 , Jelica Bjekic-Macut 2 , Danijela Vojnovic Milutinovic 3 , Milan Petakov 1 , Bojana Popovic 1 , Sanja Ognjanovic 1 , Tatjana Isailovic 1 , Valentina Elezovic 1 , Dusan Ilic 1 & Svetozar Damjanovic 1
1Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia; 2Clinical-Hospital Center “Bežanijska kosa”, Belgrade, Serbia; 3Institute for Biologic Investigations “Siniša Stanković”, Belgrade, Serbia.
Introduction: Women with polycystic ovary syndrome (PCOS) are characterized with insulin resistance and hyperinsulinaemia. Adiponectin and leptin are adipose tissue-specific products and are correlated with insulin resistance. The aim of the study was to access the relation of adiponectin with anthropometric, metabolic and hormonal parameters in a group of women with PCOS.
Methods: We studied 57 non-obese women with PCOS diagnosed using ESHRE/ASRM criteria (PCOS: age 24.8±5.6 years, BMI: 22.6±3.8 kg/m2) and 22 BMI-matched healthy women (controls: age 27.8±4.9 years, BMI: 21.8±3.3 kg/m2). Whole body fat mass (WBFM) and abdominal fat mass (AFM) were determined by bioelectric impedance (Tanita). In all subjects serum concentrations of glucose, insulin, total cholesterol (TC), HDL, LDL, triglycerides, adiponectin, leptin, testosterone, and SHBG were determined. HOMA was calculated using standard formula.
Results: PCOS had more WBFM in comparison to controls (18.47±7.68 kg vs 13.02±5.83 kg, P=0.004), while there was no difference in AFM between groups. PCOS had higher testosterone (2.6±1.0 vs 1.7±1.0 nmol/l; P<0.001) and lower SHBG (42.3±26.1 vs 64.3±29.9 nmol/l; P<0.001). There were no differences between PCOS and controls in adiponectin (8.4±3.5 vs 9.8±3.8 μg/ml; P=0.15), leptin (19.1±17.9 vs 16.4±16.1 μg/ml; P=0.47), and HOMA index (3.3±1.8 vs 3.2±1.7; P=0.76). There were no differences between groups in other measured parameters. Positive correlation in both groups was found between adiponectin and HDL (PCOS: r=0.46, P<0.001; controls: r=0.53, P=0.01), and leptin with WBFM (PCOS: r=0.71, P<0.001; controls: r=0.68, P=0.001), AFM (PCOS: r=0.63, P<0.001; controls: r=0.73, P=0.001) and HOMA (PCOS: r=0.41, P=0.002; controls: r=0.52, P=0.016). Leptin had negative correlation with SHBG only in PCOS group (r=−0.42, P=0.001). Other measured parameters did not correlate with leptin and adiponectin in both groups.
Conclusion: We did not show difference in plasma adiponectin and leptin concentrations between our group of PCOS women and BMI matched healthy controls. Leptin showed better correlation with obesity and insulin resistance in comparison to adiponectin in both groups. Analyses on larger number of subjects for the relation of adipokines with metabolic indices in PCOS is needed.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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