ECE2013 Poster Presentations Female reproduction (47 abstracts)
Metabolic features in patients with polycystic ovary syndrome (PCOS) during different stages of reproductive life
Teresa Sir-Petermann , Amanda Ladron de Guevara , Barbara Echiburu , Nicolas Crisosto , Natalie Vantman , Cecilia Pereira , Francisco Perez-Bravo & Jose Galgani
University of Chile, Santiago, Chile.
Polycystic ovary syndrome (PCOS) is an important metabolic and reproductive disorder which confers substantially increased risk for type two diabetes and metabolic syndrome (MS). Our aim is to characterize the metabolic profile, insulin sensitivity (IS) and insulin secretion in control (Cw) and PCOS women (PCOSw) during different stages of reproductive life (S1: 18–35 years old, S2: 36–44 years old, S3: 45–55 years old). A total of 131 Cw and 129 PCOSw were included, distributed as follows: S1: 69 Cw and 78 PCOSw, S2: 46 Cw and 40 PCOSw, S3: 16 Cw and 11 PCOSw. Clinical and anthropometric characteristics were evaluated. In both groups, a 2 h, 75 g OGTT was performed with measurement of glucose, insulin and lipids. HOMA-IR, insulin sensitivity index (ISI) composite, HOMAbeta, insulinogenic index and area under the curve for glucose and insulin were calculated. MS was evaluated according to the modified NCEP ATP III criteria. Chronological age, BMI, anthropometrics and fasting glucose were similar between Cw and PCOSw in the three study periods; 2-h glucose increased with age in PCOSw. Stage 1 and 2 PCOSw showed a higher prevalence of hypertension, hypercholesterolemia and hypertriglycerides compared to CW.
| S1 | S2 | S3 | ||||
| Cw | PCOSw | Cw | PCOSw | Cw | PCOSw | |
| ISI composite | 6.4 (1.2–23) | 4.4* (0.4–11) | 6.6 (1.4–21) | 5.0* (0.8–12) | 5.3 (1.6–8) | 4.6 (0.7–4.7) |
| Homa-B | 383 (60–4420) | 327 (60–1226) | 230(41–1079) | 180 (26–484) | 183 (76–377) | 176 (48–321) |
| Insulinogenic index | 2.6 (0.1–26.6) | 2.8 (0.1–12.6) | 1.3 (0.1–6.6) | 1.9 (0.1–6.5) | 1.6 (0.3–5.1) | 1.9 (0.5–6.6) |
| AUC insulin | 7060 (1627–26269) | 11383 * (2289–40673) | 6303 (975–35881) | 9331* (1809–33392) | 6134 (3263–14730) | 7769 (1637–31880) |
| MS (%) | 13 | 25* | 18 | 34* | 13 | 18 |
The present study shows that during reproductive age, PCOSw are more affected metabolically than Cw. Nevertheless during the perimenopausal period, Cw are metabolically more perturbed showing a similar metabolic profile to PCOSw.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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