ECE2013 Poster Presentations Female reproduction (47 abstracts)
The assessment of metabolic derangements including metabolic syndrome in relation to the degree of hyperandrogenism in women with polycystic ovary syndrome
Jelica Bjekic-Macut 1 , Ivana Bozic Antic 2 , Dimitrios Panidis 3 , Danijela Vojnovic Milutinovic 4 , Olivera Stanojlovic 5 , Milan Petakov 2 , Bojana Popovic 2 , Tamara Bogavac 2 , Sanja Ognjanovic 2 , Tatjana Isailovic 2 , Valentina Elezovic 2 , Dusan Ilic 2 & Djuro Macut 2
1Clinical-Hospital Center “Bežanijska kosa”, Belgrade, Serbia; 2Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia; 3Division of Endocrinology and Human Reproduction, 2nd Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Thessaloniki, Greece; 4Institute for Biologic Investigations “Siniša Stanković”, Belgrade, Serbia; 5Institute for Physiology, Medical Faculty, University of Belgrade, Belgrade, Serbia.
Introduction: Polycystic ovary syndrome (PCOS) is associated with a higher risk for development of metabolic syndrome (MS). In this study, we evaluated the degree of metabolic disorders in women with PCOS and different degree of hyperandrogenism (HA).
Methods: We analyzed 234 women with PCOS (group PCOS; BMI: 22.4±3.6 kg/m2, age: 24.8±4.7 years) diagnosed on the basis of ESHRE/ASRM criteria, and 45 healthy BMI-matched women who comprised the control group (group controls; BMI: 21.3±3.2 kg/m2, age: 28.3±4.9 years). Women with PCOS were divided into three subgroups according to the presence of HA: i) with biochemical HA (n=123), ii) with clinical HA (n=61), and iii) without clinical or biochemical HA (n=50). In all subjects, basal blood samples were collected in follicular phase of menstrual cycle for determination of glucose, insulin, total cholesterol (TC), HDL, LDL, triglycerides, apolipoproteins A1, A2, B and E, lipoprotein(a), C-reactive protein (CRP) and uric acid. HOMA index was calculated using standard formula, and lipid ratios TC/HDL, LDL/HDL, triglycerides/HDL, ApoB/ApoA1 were determined. MS was diagnosed according to JIS criteria.
Results: In comparison to PCOS subgroup B and C, PCOS subgroup A had higher triglycerides (P<0.001 and P=0.012) and CRP (P=0.032 and P=0.022), lower ApoA1 (P=0.045 and P=0.007), and higher TC:HDL ratio (P=0.02 and P=0.007) and triglycerides:HDL ratio (P<0.001 and P=0.001), respectively. PCOS subgroup A in comparison to PCOS subgroup C had significantly lower HDL (P<0.001) and higher ApoB:ApoA1 ratio (P=0.045). There was higher prevalence of MS in PCOS subgroup A (21%) in comparison to groups B (3%) and C (3%), P<0.001.
Conclusion: PCOS women with biochemical HA had unfavorable lipid profile and higher prevalence of MS than PCOS women without hyperandrogenemia.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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