Endocrine Abstracts

Introduction: Acromegaly is a relatively rare disease with numerous complications. Our aim is to look for visceral abnormalities and tumour development in subjects with GH and insuIin like GH (or IGF1) excess.

Subjets and methods: It is a retro-and prospective study that takes in account 112 patients at diagnosis, with pur pituitary tumours secreting GH, or mixed tumours secreting prolactin and GH diagnosed between 1980 and 2012. They all were questioned and examined. They also had heart (clinical, ECG and echosonography), pulmonary (clinical±polysomnography), gastro intestinal (coloscopy, abdomen ultrasound (US)), thyroid (US±scintigraphy), prostatic (US, total and free prostatic acid phosphates: n=16), and bone (standard radiographs, bone mineral density) explorations.

Results: High blood pressure was observed in 31.53%, cardiomyopathy in 33.65% and sleep apnea (SA)=15%. Severe bone abnormalities were seen in 12.12%. For organomegaly, we observed 75% benign prostatic hypertrophy, 40% goiters, 13% splenomegalies and 7.89% hepatomegalies. Concerning neoformations, we observed 7.89% colonic polyps and 2 (1.7%) thyroid cancers.

Conclusion: In this group, cardiovascular complications, prostatic hypertrophies, and organomegalies are as frequent as in literature reports. For SA our results are certainly under estimated. For colonic polyps and malignant tumours our results seem to be low compared to some authors’ results.