ECE2013 Poster Presentations Endocrine tumours and neoplasia (66 abstracts)
Adrenal lesions in patients with neuroendocrine tumors
Bojana Popovic 1 , Djuro Macut 1 , Milan Petakov 1 , Ivana Bozic 1 , Tamara Bogavac 1 , Tatjana Isailovic 1 , Sanja Ognjanovic 1 , Valentina Elezovic 1 , Marjan Micev 2 , Nemanja Menkovic 3 , Dusan Ilic 1 & Svetozar Damjanovic 1
1Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Centre of Serbia, Belgrade, Serbia; 2Clinic for Gastroenterohepatology, Pathohistology Unit, Clinical Centre of Serbia, Belgrade, Serbia; 3Centre for Radiology, Clinical Centre of Serbia, Belgrade, Serbia.
Introduction: The coexistence of adrenal tumors (AT) in patients with neuroendocrine tumors (NETs) has not been extensively studied. The aim of our study was to investigate their prevalence and clinical significance in these patients.
Materials and methods: We retrospectively studied 447 patients with NETs of all localizations, treated at our department between 2004 and 2012. Diagnosis was established pathohistologically, classification performed according to stage and grade as proposed by ENETS, and disease progression monitored by CT/MRI imaging. The nature of AT was evaluated pathohistologically when possible, or by CT/MRI characteristics indicative for benign/malignant lesion. Functional status was assessed appropriately in all patients. Statistical analysis was performed by SPSS software.
Results: The prevalence of ATs was 14.3% (64 patients). The involvement was unilateral in 59.4% (42.2% left and 15.6% right adrenal) and bilateral in 40.6% of patients, with mean diameter of 30.2±20.9 mm (9–108 mm). The majority of patients had primary pancreatic NET (40.6%), followed by lung NET (28.1%), NET of unknown primary (9.4%) and intestinal NET (7.9%), while other localizations were present with less than 4.7% each. Ten patients (15.6%) had MEN1 syndrome. Metastatic nature was pathohistologically verified or was indicative by CT/MRI characteristics in majority of cases (55.6%, 35 patients), five of which (14.3%) had MEN1. Out of the remaining 29 patients with benign lesions (6.5% of all patients with NETs), size progression was noted in only one AT, and only one tumor was functionally active (subclinical Cushing’s syndrome). Adrenal involvement positively correlated with tumor grade (r=0.389, P<0.001) and stage (r=0.261, P=0.007). Overall survival of patients with coexistent AT was 77.0 months (95% CI 23.9–130.1), which was not significantly different than OS of patients without AT (P>0.05).
Conclusion: Adrenal tumors in our group of patients with NETs were mostly metastatic, but their overall clinical relevance needs further studies.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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