ECE2013 Poster Presentations Endocrine tumours and neoplasia (66 abstracts)
Neuroendocrine tumours (NETs) of lung: new data on atypical carcinoid and large cell neuroendocrine carcinoma from a French-Italian multicentric study
Francesca Marciello 1 , Olaf Mercier 2 , Piero Ferolla 3 , Planchard David 4 , Pier Luigi Filosso 5 , Alain Chapelier 6 , Franco Grimaldi 7 , Bertrand Richard de Latour 8 , Giusy Blanco 9 , Joel Guigay 4 , Guglielmo Monaco 11 , Philippe Dartevelle 2 , Mauro Papotti 10 , Jean-Yves Scoazec 4 , Annamaria Colao 1 , Eric Baudin 4 & Antongiulio Faggiano 1,
1University of Naples Federico II, Naples, Italy; 2Marie Lannelongue Hospital, Le Plessis Robinson, France; 3University of Perugia, Perugia, Italy; 4Institute Gustave Roussy, Villejuif, France; 5University of Turin, Turin, Italy; 6Foch Hospital, Suresnes Hauts-de-Seine, France; 7Santa Maria della Misericordia, University of Udine, Udine, Italy; 8Pontchaillou Hospital, University of Rennes, Rennes, France; 9Meditterranean Institut of Oncology, Viagrande, Italy; 10University of Turin at St Luigi Hospital, Orbassano, Turin, Italy; 11Cardarelli Hospital, Naples, Italy; 12National Cancer Institute G.Pascale Fundation, Naples, Italy.
Introduction: Natural history of lung neuroendocrine tumours (NETs) and in particular of two histological subtypes, atypical carcinoid (AC) and large cell neuroendocrine carcinoma (LCNEC), is poorly known.
Aim of the study was to determine disease-free survival (DFS) and overall survival (OS) of sporadic, resectable, non-metastatic lung AC and LNEC.
Patients and methods: This retrospective study involved 116 consecutive patients surgically treated (R0) between 1998 and 2008 for AC and LCNEC in two Italian and French expert networks. Slides were reviewed by two expert pathologists to validate the histological definition (WHO 2004).
Results: The files of 86 patients were reviewed (49 males and 37 females). Mean age at diagnosis was 58±15 years for AC and 63±15 years for LCNEC. The most frequent presenting symptom was respiratory infection (AC: 24%, LCNEC: 31%); endocrine syndrome occurred in only one AC patient (Cushing’s syndrome). Mean follow-up time was 80.6 months in AC and 50.6 months in LCNEC. The most used surgery was lobectomy (AC: 81%, LCNEC: 59%). N-positive status was found in 29 and 57% of AC and LCNEC respectively. The rate of recurrence was 39% among AC (15% local, 24% distant metastasis) and 41% in LCNEC (27% local, 14% distant metastasis). The mean time of recurrence from surgery was 24.6 months in AC and 15 months in LCNEC. Median OS was 5.4 years in LCNEC (not reached in AC). Median DFS was not reached in both histotypes. Recurrence rate was higher in N+ AC patients than in N0 ones (76 vs 24%).
Conclusion: Patients with lung AC and LCNEC experience a high rate of recurrence after surgery. Beside LCNEC patients, N-positive AC patients should be considered for adjuvant therapy and be subjected to an intensive monitoring on. A better definition of lung NETs prognosis and natural history is expected from large collaborative studies.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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