Endocrine Abstracts

Introduction and objectives: The aim of our study was to determine which characteristics of the uncontrolled diabetes are among randomly selected patients with type 1 (T1DM) and type 2 (T2DM) diabetes.

Material and methods: A total of 194 diabetic patients were observed, 142 with T2DM and 52 with T1DM, recruted in outpatient clinic. Patients were divided into three groups according to HbA1c values: <7% (G1), 7–8% (G2) and >8% (G3). Statistical analysis: t-test, test of proportions, multiple logistic regression analysis.

Results: Patients (G1–G3) did not differ by age, prevalence of types 1 and 2 diabetes: T1DM (59.6%; 25%; 15.4%) and T2DM (55.3%; 23.3%; 21.3%) and disease duration. G1 compared to the G3 significantly differ or with the tendency of significance in representation of males (38.6 vs 56.3%, P 0.02), triglyceridemia level (1.8±1.4 vs 1.4±0.9 mmol/l, P 0.10), fibrinogen (3.7±0.8 vs 3.4±0.8 g/l, P 0.05) and platelets (259.3±60.5 vs 230.1±60.7*10⁹/l, P 0.02) were lower (165.5±10.3 vs 169.5±10.9 cm, P 0.06), with less the used biguanides (45.6 vs 65.6%, P 0.07) and especially sulphonylurea (23.7 vs 46.9%, 0.02), and more were on insulin therapy (84.2 vs 53.1%, P <0.01), with multiple daily insulin dose (49±2 vs 37±12, P 0.01) and more frequent retinopathy (57.1 vs 36.7%, P 0.07). G1 to G2 patients were more often on insulin therapy (81.3 vs 53.1%, P 0.01).

Conclusions: Patients with glucose unregulation were characterized with clusters of components that are the part of increased insulin resistance (increased insulin dose…) and with simultaneous therapeutic inconsistency to it (metformin therapy). As a consequence, there were increased level of hemostatic components (platelets, fibronogen) and increased incidence of diabetic retinopathy.