Endocrine Abstracts

Objective: To assess the association of type II DM with hepatocelular carcinoma occurrence.

Materials and methods

It was a case control study carried out using data retrieved from the register maintained in the Department of Biochemistry of Manipal College of Medical Sciences, Pokhara, Nepal between 1st January, 2012 and 31st August, 2012. The variables collected were age, gender, HbA1c. All these biochemical parameters were analyzed in the Central Laboratory of our hospital by standard and validated methods. The One way ANOVA was used to examine the statistical significant difference between groups. Post hoc test LSD used for the comparison of means of case groups. Odds ratios (OR) were calculated using simple logistic-regression analysis.

Results: The etiological factor for 200 patients of HCC was HBV, HCV, alcohol and cryptogenic. The highest age group belongs to etiological category of HCV with mean of 71.90±3.6 (CI 69.28, 74.52) years and lowest age group belongs to etiological category of HBV with mean of 61.70±5.3 (CI 57.88, 65.52) years. The main imperative basis of HCC in present study was HCV (39.5%) and second most significant cause of HCC was alcohol (26%). Glycated haemoglobin was more in males HCC (7.9%) as compared to females (7.3%). The percentage of type II diabetes mellitus was more in HCC patients when compared to controls. This difference was statistically significant with an odd ratio of 4.63 (P< 0.001).

Conclusion: Type II DM influences incidence, risk of recurrence, overall survival, and treatment-related complications in HCC patients.