Endocrine Abstracts

Introduction: The prevalence of hyperlipidemia in type 1 diabetics is 30 to 90%. High total cholesterol, LDL and triglyceride serum level is independent risk factor for cardiovascular disease. High prevalence of malignant atherogenic profile is alarming in type 1 diabetics (high triglyceride, low HDL). It is very often that dislipidemia is associated with diabetes and obesity, as well as hypertension, that pointed to inherited disorders.

The aim of this study is to analyse lipid profile in patients with type 1 diabetes in Kragujevac depending on gender.

Methods: This study included all patients registered in Primary Care with type 1 diabetes mellitus. We determinated lipid profile: total cholesterol (tChol), LDL, HDL and tryglicerides (TAG). Patients were divided according to gender.

Results: We registered 206 patients with type 1 diabetes in Kragujevac (107 men and 99 women). Anamnesticly, previous lipid disorder had 8.2% patients. According to National Guideline Clinical Practice criteria: 55.5% has increased tChol level, 42.1% increased LDL, 29.1% increased TAG i % 33.3 decreased HDL cholesterol level. There is statisticaly significance in LDL (2.55±0.75 vs 3.0±1.18 mM, men vs women, P=0.09), but there is no significance in average tChol level (4.73±1.07 vs 5.01±1.39 mM, men vs women, P=0.379), TAG (1.4±0.98 vs 1.41±0.89 mM, P=0.94) and HDL (1.39±0.39 vs 1.42±0.38 mM, P=0.808).

Conclusion: There is some patients who know about lipid disorders, but the prevalence is high. There is statistically significantly higher LDL in women. All these results showed not satisfied liporegulation in type 1 diabetic patients.