Endocrine Abstracts

Aim: Is to determine the frequency of hypoglycemic states in patients with T1DM with and without depression.

Materials and Methods: patients with T1DM (57 men and 51 women) aged 41.15 years (34.65, 46.66) were examined, with the experience of diabetes about 11.32 years (2.80, 11.90). Depression was determined according to the scale HADS. Assessment of glycemia was carried out with the help of daily monitoring system of glucose in intercellular fluid (CGMS).

Results: The patients were divided into two groups: 1st – patients with T1DM with depression (n=47), 2nd – patients with T1DM without depression (n=61). The HbA1C level in the first group was 9.75% (8.70, 10.45) vs 8.15% (7.50, 9.45) in the second group (?(0.05).

The level of minimum glycemia in patients of the first group was 2.45 (2.20, 3.45) mmol/l vs 4.4 0 (3.50, 5.70) mmol/l in the comparison group (P <0.05);

– the duration of hypoglycemia in the first group was 2% (0, 8) vs 0% (0, 0) in the comparison group (P<0.05);

– 35 hypoglycemic states (79.54%) were recorded in the first group versus 18 (29.5%) in the second group (P(0.05);

– there were 26 (59.1%) cases of latent hypoglycemia in the first group versus 11 (18%) in the second group (P(0.05).

The relationship between increased levels of NbA1C and depression was found (RC=1.50; P=0.002; 95% CI 1.15–1.94). A similar dependence was traced when assessing the frequency of episodes of latent hypoglycemia and depression level HADS (RC=1.12; P=0.0024; 95% CI 1.02–1.24).

Conclusion: The patients with T1DM and depression had a significantly higher level of HbA1C with a lower level of minimum glycemia and a long duration of hypoglycemia. Frequent hypoglycemic episodes, including latent hypoglycemia, may be the reason of decompensation.