Endocrine Abstracts

Introduction: The aim of this study was to investigate the cardiovascular risk factors which could predict vascular thickness in diabetic patients who did not have clinical symptom of atherosclerotic vascular disease

Method: A total of 101 type 2 diabetic patients (48 males and 53 females) with a mean age of (53.6±8.4 years) were recruited in this study. CIMT were measured by B-mode ultrasonography and ankle brachial pressure index (ABI) was measured with a Doppler ultra-sound. Linear regression analysis was performed with CIMT as dependent variable and ABI and cardio metabolic risk factors as independent variables.

Result: We found that, CIMT were associated with blood pressure (β=−0.37, P=0.01), waist circumference (β=−0.21, P=0.03), TG (β=−0.12, P=0.05), and ABI (β=−0.1, P=0.07). Subsequent adjusted regression model showed, blood pressure (β=0.37, P≤0.05), waist circumference (β=−0.21, P<0.05), and TG (β=0.24, P<0.007) were identified as independent predictorsof CIMT in diabetic patients and the effect of ABI didn’t exist anymore.

Conclusion: In conclusion, the present study showed that insulin resistance index and HbA1C were not potential predictors of cardio vascular thickness in type 2 diabetic patients who exposed to diabetes at least for 9 years. While waist circumference, systolic blood pressure and triglyceride were associated with CIMT in these patients.

Key Words: Carotid intima media thickness (CIMT), ankle brachial pressure index (ABI), cardio metabolic risk factors, Insulin resistance, HbA1c, type 2 diabetes.