Endocrine Abstracts

Aim: The aim of our study is to assess the efficacy of a lifestyle modification including altered diet composition and physical activity in preventing diabetes mellitus type 2 (DM 2) in individuals with impaired glucose tolerance and impaired fasting glucose (IGT/IFG) and influence it on changes serum leptin levels

Materials and methods: The study included 327 patients with IGT/IFG (68 males and 258 females) 25–65 years. Patients were divided into two groups matched by sex, age, weight, and BMI. Research group included 183 patients (32 males and 150 females) who received and carried out individual recommendations of a balanced diet and physical activity. Control group included 144 patients (36 males and 108 females) who did not lifestyle modification. Related to fasting leptin (FL) concentrations by sensitive ELISA.

Results: Patients of the research group demonstrated reduction of body weight (P<0.01). They had positive dynamics of FPG and 2-h PG concentrations also (P<0.001). Persons of the control group had significant increase in weight and BMI and FPG and 2-h PG concentrations elevated (P<0.05). The main novel finding was that median serum leptin in research group decreased on −23.9% (P<0.01) and increased in control group on +27.6% (P<0.01) among subjects with IGT Among patients of the research group was a reduction of new care DM 2 by 11.9% and an increase in the control group by 35.1%.

Conclusion: Thereby, lifestyle modifications lead to reduction not only fasting plasma glucose, postprandial glucose concentrations but and fasting leptin concentrations in individuals with IGT/IFG.