Endocrine Abstracts

Insulin resistance (IR) has been proven to increase the risks for cardiovascular complications in type 2 diabetes mellitus. Recently, IR has also been shown to play a bigger role in the natural history of type 1 diabetes mellitus (T1DM) disease process than is commonly recognized. The objectives of this study are to determine the prevalence of IR among Filipino adults with T1DM and to describe the clinical features of T1DM with IR.

This cross-sectional analytic study recruited 83 adults with established T1DM in Philippine General Hospital. Mixed-meal stimulated C-peptide level was done to confirm the diagnosis of T1DM. IR was determined using estimated glucose disposal rate (eGDR) with the formula of: eGDR=24.31 (12.22×waist-to-hip ratio) – (3.29×1 if with hypertension or on anti-hypertensive or ×0 if no hypertension) – (0.57 × HbA1c). Subjects with eGDR of ≤7.5 mg/kg per min were considered to have IR.

The prevalence rate of IR was found to be 53%. T1DM subjects with IR were significantly older (29.59 vs 25.59, P=0.007), with longer duration of diabetes (59.7 vs 40.3% with duration of diabetes >5 years, P=0.037), with higher waist-to-hip ratio (0.95 vs 0.93, P=0.005) and with higher rate of hypertension (100 vs 0%, P=0.00) than those without IR.

The study showed a high prevalence rate of IR among Filipino adults with established T1DM. Hypertension, older age, longer duration of disease and a higher waist-to-hip ratio are the features of T1DM with IR.