ECE2013 Poster Presentations Cardiovascular Endocrinology & Lipid Metabolism (41 abstracts)
Post prandial responses in insulin, free fatty acid and endothelial function following to Malaysian vs Mediterranean meals among healthy subjects
Norasyikin A Wahab , Yusniza Yusoff , Amiliyaton Mohd Razali , Suehazlyn Zainudin , Rohana Abd Ghani , Norlela Sukor , Norlaila Mustafa , Shamsul Azhar Shah , Barakatun Nisak Mohd Yusof & Nor Azmi Kamaruddin
Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia.
Introduction: Refined carbohydrates, which constitute the staple diet in most cultures may exaggerate postprandial responses in term of insulin, free fatty acid and vascular function. These changes may contribute the onset of metabolic syndrome and diabetes among those at high risk of developing these diseases.
Objective: To determine the postprandial insulin, free fatty acids levels and endothelial function responses in healthy subjects to two different breakfast meals, Mediterranean vs Malaysian diet with different carbohydrate contents, glycaemic index and glycaemic load.
Methods: Twenty subjects were made to take two different meals, Mediterranean meals; low Glycaemic Index (GI) and low Glycaemic Load (GL) and Malaysian meals (high GI and high GL) a week apart. Blood parameters including fasting serum lipid, serum insulin, serum non esterified free fatty acid were taken at 0, 30, 60, 90, and 120 min after each meals. Blood glucose was also taken at baseline and 120 min postprandially.
Results: Twenty subjects were randomized to either Mediterranean meal or Malaysian meal. Baseline clinical and demographic data parameters were comparable for both meals. With both meals there was an increased in serum triglyceride with a corresponding drop in HDL and LDL levels throughout the 2-h postprandial period. There is a significant increase in the serum insulin level with Malaysian meal (P=0.002) compared to Mediterranean meal (P=0.012). However, the non esterified fatty acid levels were significantly lower in Malaysian meal (P=0.001) compared to Mediterranean meal.
Conclusion: Malaysian meal which is characterised by high GI and GL stimulated significant increase in insulin responses in the setting of significant drop in free fatty acid compared to Mediteranean meal.
Key Words: insulin; serum nonesterified fatty acid (NEFA).
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Endocrine Abstracts
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