ECE2013 Poster Presentations Cardiovascular Endocrinology & Lipid Metabolism (41 abstracts)
Linear growth and IGF1 concentrations in children cyanotic and acyanotic congenital heart disease before vs after intervention
Ashraf Soliman 1 , Khaled Ellithy 1 , Ayman Khella 1 , Haytham Yassin 1 , Emad Shatla 1 , Aml Sabt 1 & Rania Elalaily 2
1Hamad Medical Center, Doha, Qatar; 2Primary Health Care, Doha, Qatar.
Objectives: To measure linear growth of patients and the magnitude of catch-up growth and changes and IGF1 concentration.
Design: This prospective study recorded the anthropometric data and measured the IGF1 of 32 infants and children with congenital acyanotic heart disease (CAHD) with left to right shunt (14 VSD, 10 ASD, and 8 PDA) without heart failure, and 15 with cyanotic heart disease (CCHD) before (B) and a year after (A) surgical or catheter intervention.
Results: At presentation patients with CHD height SDS (HtSDS) and GVSDS were significantly decreased vs normal controls. The BMI of CCHD were significantly lower than normal controls. Before intervention, CCHD had significantly decreased length SDS (LSDS) and growth velocity SDS (GVSDS) vs CAHD. One year after intervention the HtSDS, GVSDS increased significantly in patients with CCHD and CAHD. After intervention CCHD had higher GVSDS compared to children with CAHD. BMI increased significantly in patients with CCHD after intervention. IGF1 levels increased significantly in both groups of patients after intervention. The HtSDS after treatment was correlated with the IGF1 concentration (r=0.70, P<0.001). In CAHD the shunt size was correlated negatively with BMI before intervention (r=0.39, P<0.01). GVSDS after intervention surgery was correlated with age at operation (r=−0.62, P<0.001) and BMI after intervention (r=0.57, P<0.001).
| Patients (n) | CCHD-B=15 | CCHD-A=15 | CAHD-B=32 | CAHD-A=32 | Controls-B=50 | Controls-A=50 |
| Age mon | 11.9 | 24.6 | 30 | 43.2 | 18.5 | 32.4 |
| LSDS | −2.6 | −1 | −1.1 | −0.55 | −0.2 | −0.1 |
| GVSDS | −1.3 | 3.5 | −0.7 | 2.5 | 0.31 | 0.25 |
| BMI | 14.5 | 16.4 | 15 | 15.7 | 16.3 | 16.7 |
| IGF1 (ng/ml) | 41.5 | 72.3 | 53 | 79 | ND | ND |
Conclusions: These data denoted that early surgical interference and good weight gain have beneficial effect on postoperative growth spurt.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more