Comparative study of bone metabolic parameters and vitamin D levels of fertile aged women, suffering from different bone metabolism altering diseases

Orsolya Acs; BenceT Acs; Csaba Horvath; Viktoria Ferencz; Szilvia Meszaros; Edit Toth; Emoke Csupor

doi:10.1530/endoabs.32.P158

P158

Prev Next

Section Contents Cite

Endocrine Abstracts (2013) 32 P158 | DOI: 10.1530/endoabs.32.P158

ECE2013 Poster Presentations Calcium and Vitamin D metabolism (62 abstracts)

Comparative study of bone metabolic parameters and vitamin D levels of fertile aged women, suffering from different bone metabolism altering diseases

Orsolya Acs ¹ , BenceT Acs ^1, , Csaba Horvath ³ , Viktoria Ferencz ³ , Szilvia Meszaros ³ , Edit Toth ⁴ & Emoke Csupor ⁵

Err

Author affiliations

¹Semmelweis University School of Ph.D. Studies, Budapest, Hungary; ²2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary; ³1st Department of Internal Medicine, Semmelweis University, Budapest, Hungary; ⁴Department of Rheumatology, County Hospital Flor Ferenc, Budapest, Hungary; ⁵The Health Service of Budavari Local Authorities, Endocrinology, Budapest, Hungary.

Introduction: Polycystic ovary syndrome (PCOS), lactase deficiency, nephrolithisasis and thyroid diseases are considered endemic. The aim of our study was to evaluate which of the above-mentioned diseases affect the most the bone metabolic parameters, bone mineral density (BMD) and the prevalence of bone fractures in fertile aged women.

Materials and methods: A total of 92 fertile aged women (32.6±5.2 years) were divided into four groups (23 in each) according to their diseases (PCOS or lactase deficiency or nephrolithiasis or treated hypothyroidism). BMD was measured by dual-energy X-ray absorptiometry (DEXA). Laboratory analysis included routine and also calcium metabolism: 25-hydroxyvitamin D (25-OHD₃), parathyroid hormone (PTH), β-CrossLaps, 25-OH D₃-vitamin D, osteocalcin (OC). The prevalence of bone fractures were also recorded. Statistical analysis was performed by ANOVA, with post-hoc Bonferroni’s correction (Satistica Software 9.0).

Results: After comparing the results of the groups, women with nephrolithiasis had the lowest BMD (Zsc: −0.92±0.35) (P<0.05) in the region of lumbar spines (L2–4), the lowest BMD (Zsc: −1.33±0.43) (P<0.05) in the region of the femoral neck, and lowest BMD (Zsc: −1.1.9±0.31) (P<0.05) at the one third of distal radius among all groups. The average bone fracture rate of the 92 fertile aged women was high (40.8%), and serum 25-(OH) vitamin D₃ levels were low (27.8±6.1–36.4±6.4 nmol/l) comparing to the normal range.

Conclusion: The recognition and treatment (for e.g. sufficient supplementation of vitamin D) of endemic diseases in women in fertile age should become part of the osteological and fracture prevention.