Efficacy of vitamin D on COPD exacerbation: a double blind randomized placebo-controlled clinical trial

Mojgan Sanjari; Akbar Soltani; Abdolrahim Habibi Khorasani; Mostafa Shokoohi; Maryam Zareinejad

doi:10.1530/endoabs.32.P116

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Endocrine Abstracts (2013) 32 P116 | DOI: 10.1530/endoabs.32.P116

ECE2013 Poster Presentations Calcium and Vitamin D metabolism (62 abstracts)

Efficacy of vitamin D on COPD exacerbation: a double blind randomized placebo-controlled clinical trial

Mojgan Sanjari ¹ , Akbar Soltani ² , Abdolrahim Habibi Khorasani ³ , Mostafa Shokoohi ⁴ & Maryam Zareinejad ⁵

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¹Physiology Research Center, Kerman University of Medical Sciences, Iran, Kerman, Iran; ²Endocrine Research Center and Department of Endocrinology Tehran University of Medical Sciences, Tehran, Iran; ³Department of Pulmonary Medicine, Kerman University of Medical Sciences, Kerman, Iran; ⁴Research Center for Modeling in Health, Kerman University of Medical Sciences, Kerman, Iran; ⁵Department of Internal Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Background: Exacerbations are an important feature and outcome measure in chronic obstructive pulmonary disease (COPD). The objective of this study was to investigate the effect of supplementation of standard treatment (inhaled long-acting β2 agonists, anticholinergics and corticosteroids) with vitamin D on pulmonary function tests in patients with COPD exacerbation.

Methods: Patients referred to hospital were divided into three groups receiving 0.25 μg calcitriol daily (n=45), 50 000 IU daily of vitamin D (n=45) and placebo (n=45). Spirometry and clinical assessment were carried out at the beginning and after 1 week treatment.

Results: There was a similar degree of lung function and clinical improvement in all three groups (P>0.05). C-reactive protein level did not significantly different among three groups of treatment at 1 week after treatment.

Conclusions: Our findings showed that 1 week supplementation of treatment with 50 000 IU daily of vitamin D₃ or 0.25 μg calcitriol daily did not provide any additional clinical benefit.