Endocrine Abstracts

Aim: The aim of this study is evaluating trabecular bone score (TBS) and bone mineral density (BMD) in normal women depending on duration of postmenopausal period (PMP).

Materials and methods: We’ve examined 122 normal women aged 40–79 years (mean age – 56.2±0.8 years; mean height – 162.6±0.5 cm; mean weight – 71.5±1.3 kg), who were divided into the groups depending on duration of PMP: without menopause (with normal menstrual cycle) (n=25), 1–3 years (n=26), 4–6 years (n=12), 7–9 years (n=18), 10–12 years (n=8), 13–15 years (n=4), 16-18 years (n=5), more 19 years (n=7). BMD of total body, lumbar spine and femoral neck and TBS (TBS iNsight software package, Med-Imaps) were measured by DXA using a densitometer Prodigy, GE.

Results: We have determined the significant decrease of TBS (L1–L4) in women with age (F=4.52; P=0.0001). Duration of PMP has a significant influence on the variability of BMD of spine (F=3.20; P=0.004), BMD of femoral neck (F=5.41, P<0.000) and TBS (with normal menstrual cycle – 1.36±0.02/mm, 1–3 years – 1.31±0.02/mm, 4–6 years – 1.22±0.04/mm, 7–9 years – 1.23±0.03/mm, 10–12 years – 1.21±0.04/mm, 13–15 years – 1.16±0.08/mm, 16–18 years – 1.15±0.06/mm, more 19 years – 1.15±0.03/mm; F=5.70; P<0.000).

The analysis using Scheffe’s test shows that TBS was significantly lower in women with duration of PMP more 4 years (4–6 years (P=0.003), 7–9 years (P=0.002), 10–12 years (P=0.002), 13–15 years (P=0.0003), 16–18 years (P=0.0003), and more 19 years (P=0.00002)) in compare with women without menopause; BMD of spine significantly decreased in women with duration of PMP 7–9 years (P=0.02), 10–13 years (P=0.003), and more 19 years (P=0.0001).

Conclusion: TBS is independent parameter which has potential diagnostic value without bone mineral density. TBS was significantly decreased with age. Duration of PMP has a significant influence on the variability of TBS, BMD of spine and femoral neck. TBS significantly decreased in women in early postmenopausal period.