ECE2013 Poster Presentations Bone and Osteoporosis (41 abstracts)
Influence of some traditional risk factors for osteoporosis on bone metabolism during substitution therapy of primary hypothyroidism
Radoslav Pejin , Milena Mitrovic , Jovanka Novakovic-Paro , Dragana Tomic-Naglic , Branka Kovacev-Zavisic , Dragan Tesic , Milica Medic-Stojanoska , Dusan Tomic , Ivana Bajkin & Ljiljana Todorovic-Djilas
Clinic for Endocrinology, Diabetes, and Metabolic Disorders, Clinical Centre of Vojvodina, Hajduk Veljkova 1, Novi Sad, Serbia.
Relation between thyroid hormones and bone metabolism markers in hyperthyroidism is well known. Earlier studies indicate possibility of bone metabolism acceleration during the excessive replacement therapy with L-thyroxine in hypothyroid patients especially in one with other risk factors for bone metabolism impairment. This study evaluated the effect of physiological L-thyroxine treatment on bone metabolism in patients with primary hypothyroidism.
In a study group of 30 hypothyroid patients individual L-thyroxine replacement was performed targeting euthyroid status. Bone and calcium metabolism parameters (osteocalcin-OC, alkaline phosphates-ALP, C-terminal cross-linking telopeptide type I-CL, parathormone-PTH, Ca, ionized Ca, P), thyroid hormone levels (T3, T4, TSH) were measured before treatment and when euthyroid status was achieved.
In this study the following parameters were examined: influence of BMI, physical activity, time of menarche, duration of lactation period, number of children and occurrence of menopause before therapy and when the euthyroid status was achived on bone metabolism markers.
Significant difference by dispersive analysis was found in bone metabolism markers concerning influence of menopause, physical activity and BMI in treated hypothyroid patients. We did not found significant difference in bone metabolism markers among groups concerning parameters like duration of lactation period or number of live born children.
Key Words: Hypothyroidism, bone and bone metabolism, L-thyroxine substitution therapy, risk factors for osteoporosis.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more