Endocrine Abstracts

Paraganglioma is a tumor developed in expenses of the sympathetic or parasympathetic nervous system. It is a rare pathology (prevalency 1 for 30 000). These are situated on the basis of skull, at the level of neck, in the thorax and the belly. Some paraganglioma are functional and secrete cathecolamines and others are diagnosed after surgery in the histological study of the operating piece. Through a retrospective study concerning height patients having paraganglioma extra sur...

Chronic kidney disease (CKD), with or without dialysis, often prompt biochemical tests for pheochromocytoma diagnosis due to high blood pressure, hemodynamic instability or association with certain genetic syndromes. Our objective was to assess plasma free metanephrine and normetanephrine in CKD disease patients, with or without dialysis.Methods: Plasma free metanephrine and normetanephrine were measured by an enzyme-linked immunosorbent assay in 42 pati...

Paragangliomas (PGLs) are rare neuroendocrine tumors. About 30–40% of these tumors are mutated in different susceptibility genes, including those encoding the different subunits of the succinate dehydrogenase, a complex involved both in the tricarboxylic acid cycle and in the oxygen transport chain. The aim of this project was to investigate whether SDHB mutations may account for alterations in cell metabolism and functions. Since PGL cell lines are not available, we used...

Adrenal ganglioneuroma (AGN) is a rare neoplasm derived from the neural crest. It can be found along the paravertebral sympathetic plexus. Mean age at presentation is below 20 years. Most patients with AGN are asymptomatic and diagnosis is usually incidental.Case report: Fourty three-year-old man with a personal history of hypertrophic cardiomyopathy in whom a follicular small cell non-Hodgkin lymphoma (NHL) was diagnosed after a biopsy of a left supracl...

Background and aims: Pheochromocytomas arise from chromaffin cells of adrenal medulla and sympathetic ganglia. It occurs in about 0.05 to 0.1% of patients with sustained hypertension. It is considered that about half the patients with pheochromocytoma have only paroxysmal hypertension. Pheochromocytoma is usually suggested by the history in a symptomatic patient, discovery of an incidental adrenal mass, or the family history in a patient with familial disease. We retrospective...