Endocrine Abstracts

The occurrence of Cushing’ syndrome in pregnancy is a rare entity due to hypogonadism. Its diagnosis and treatment are very difficult because pregnancy causes hormonal and physical changes which can lead to confusion. In addition, the therapeutic opties are limited because of reduced fetal risk. We rereport the observations of three patients who presented severe Cushing’ syndrome appeared in the first part of pregnancy. This is unkown despite a very evocative painting. Hypercorticism is complicated by diabetes mellitus, arterial hypertension and death fetal in utero. The paraclinical exploration was in favor for no ACTH dependant hypercortisolism in two cases with a voluminous adrenocortical carcinoma (15 and 20 cm) and metastatic liver and bone and adrenal adenoma (6 mm) in the third patient. Adrenalectomy was realized to her while partial tumor excision was practiced in the others. Complementary therapy (anticortisolic mitotic and chemotherapy) is realized. The diagnosis of Cushing’s syndrome in a pregnant woman must be recognized early cause of morbidity and mortality maternofetal increased. If signs can be attributed to pregnancy such weight gain, hypertension or diabetes mellitus, other elements should attract attention as signs of hyperadrogenism, or signs of hypercatabolism. The adrenal adenomas and adrenocortical carcinomas are the two main cases. The reason for this preponderance is unclear: less hypogonadism?, HCG?, oestrogens?, progesterone?. If adenoma is effectively treated by surgery, pregnancy is very harmful scalability and prognosis of adrenocortical whose resection is often difficult and incomplete.