Endocrine Abstracts

Classically aldosterone acted uniquely on epithelia, and primary aldosteronism (PA) was considered uncommon and relatively benign, all of which we now know to be not the case. In 2013, we should note that:i). Mineralocorticoid receptors (MR) evolved millions of years before aldosterone.ii). Cortisol occupies 90–99% of all MR in the human body.iii). MR are promiscuous, binding cortisol, aldosterone and pr...