Endocrine Abstracts

A C Bianco is a professor of medicine and Chief of the Division of Endocrinology, Diabetes and Metabolism at the University of Miami Miller School of Medicine. Dr A C Bianco obtained his MD, PhD and clinical training in internal medicine and endocrinology in Sao Paulo, Brazil. His work has established the importance of the local control of thyroid hormone activation/inactivation via deiodination, as well as fundamental cellular and molecular properties of the deiodinases (D1, D2 and D3). He has also helped to elucidate the three-dimensional structure of the deiodinase-ubiquitination complex, demonstrating that ubiquidation-deubiquidation controls local T₃ production by affecting D2 dimerization. This constitutes a posttranslational on/off switch controlling thyroid hormone action in the settings of development, health and disease.

Partly supported by the Clinical Endocrinology Trust