SFEBES2013 Poster Presentations Cytokines and growth factors (4 abstracts)
Genes for IGF2 and related IGF binding proteins are associated with longitudinal trends in BMI
Ram Prakash Narayanan 1 , Bo Fu 2 , Antony Payton 3 , Rachelle Donn 4 , Adrian Heald 1 , William ER Ollier 3 & Martin Gibson 1
1Vascular Research Group, The University of Manchester, Salford, UK; 2School of Community-based Medicine, The University of Manchester, Manchester, UK; 3Centre for Integrated Genomic Medical Research, The University of Manchester, Manchester, UK; 4Musculoskeletal Research Group, School of Translational Medicine, The University of Manchester, Manchester, UK.
High IGF2 has been associated with longitudinal weight loss. We wished to study associations of genes coding for IGF2 and for binding proteins that have preferential IGF2 affinity (IGFBP2, IGFBP5 and IGFBP6) in 991 Caucasian subjects from Salford with type 2 diabetes.
Fifteen IGF2, four IGFBP2, eight IGFBP5 and one IGFBP6 SNPs were successfully genotyped. Longitudinal BMI data for the years 2002 to 2009 was obtained from integrated primary care and hospital electronic medical records. Mixed effects regression analyses were used to study SNPs as predictors of longitudinal BMI in models adjusted for age, gender and prescription of common diabetes medications that could affect weight (metformin, sulphonylureas, thiazolidinediones and insulin).
IGF2 rs12417332 and IGFBP5 rs4674107 was associated with weight gain, while IGFBP2 rs7603372, IGFBP2 rs9341105, IGFBP5 rs741384 and IGFBP5 rs7426116 were associated with longitudinal weight loss. When all the significantly associated proteins were taken together in a stepwise regression model along with age, gender and the earlier medications as covariates, associations for three SNPs – IGFBP2 rs9341105 (β=−0.12, 95% CI −0.20 to −0.04, P=0.001), IGFBP5 rs741384 (β=0.12, 95% CI 0.06 to 0.18, P<0.001) and IGF2 rs12417332 (β=−0.12, 95% CI −0.22 to −0.023, P=0.016) remained.
IGF2 has been previously reported to have longitudinal associations with weight change, and the biding proteins IGFBP2 and IGFBP5 can potentially modify IGF bioavailability. This study suggest that gene variations for all these proteins can partly determine longitudinal weight trends in diabetes.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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