Endocrine Abstracts

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HIV-1-infected patients under antirretroviral treatment develop the so-called ‘lipodystrophy syndrome’. It is characterized by peripheral lipoatrophy (face, limbs), visceral lipohypertrophy, and, sometimes abnormal accumulation of subcutaneous fat in specific sites, especially the dorso-cervical area. The abnormal fat distribution is associated with systemic alterations characteristic of the metabolic syndrome (dyslipidemia, insulin resistance). Drugs are importantly...

Lipodystrophy is a group of rare disorders characterized by complete or partial loss of adipose tissue. Lipodystrophy can be inherited or acquired and may present in childhood or in adults. Metabolic sequelae of lipodystrophy include severe insulin resistance (SIR), type 2 diabetes, hypertriglyceridaemia, hepatic steatosis and hyperandrogenism. Research in our centre has produced a database of several hundred patients with lipodystrophy and/or SIR and has contributed to identi...