SFEBES2013 Poster Presentations Pituitary (71 abstracts)
Long-term results after treatment of craniopharyngioma: experience with 46 adult patients
Cristina Capatina 1, , Maria Preda 1 , Anda Dumitrascu 2 , Dan Hortopan 2 , Andra Caragheorgheopol 2 , Daniela Alexandrescu 2 , Vasile Ciubotaru 3 , Mihail Coculescu 1, & Catalina Poiana 1,
1‘Carol Davila’ University of Medicine and Pharmacy, Bucharest, Romania; 2‘C.I.Parhon’ National Institute of Endocrinology, Bucharest, Romania; 3‘Bagdasar-Arseni’ Emergency Hospital, Bucharest, Romania.
Background: Craniopharyngioma is a rare, mostly benign tumor of the central nervous system, generally associated with important morbidity.
Aim: To study the clinical characteristics and treatment outcome in adult patients.
Methods:: Adult patients diagnosed with craniopharyngioma between 1980 and 2012, followed-up in the Pituitary and Neuroendocrine Department of the ‘C.I.Parhon’ National Institute of Endocrinology in Bucharest were retrospectively evaluated. We studied the presenting symptoms, complications at diagnosis, type of treatment, surgical complications, rate of tumor resection, endocrinological and visual outcome.
Results: A total of 46 patients (18 females, 28 males aged between 18 and 72 years, median 35.4 years) with a mean follow-up of 7.33 years (1–41 years) were included. The presenting symptoms were mostly headache (86.95%), visual impairment (78.26%), symptoms of hypopituitarism (30.42%), diabetes insipidus (DI) (8.69%), hydrocephalus (15.21%); the median time to diagnosis was 12 months. All tumors had sellar and suprasellar component, the mean craniocaudal diameter was 2.58 cm (range 1 – 5.6 cm). All patients were operated (69.56% – transfrontal approach, 26.08% trassphenoidal, 4.34% – frontotemporal); in most cases repeated surgery was necessary due to recurrence or remnant growth. six cases received adjuvant radiotherapy. In only 13 cases (28.26%) gross-total removal (GTR) was achieved (3 subsequently recurred), in 71.73% of cases a tumor remnant (diameter between 0.4 and 5 cm) was present. 32.6% developed permanent DI. Visual field improved in 15.21% (normalized in four cases), worsened in 36.95% and remained stable in 45.65%. Two hypopituitary cases normalised, in all others (89.13%) hypopituitarism remained or worsened with treatment. Only 56.52% of cases could return to their usual activity. Weight gain was significant: 38% of normal or overweight cases became obese.
Conclusions: Craniopharyngiomas are often associated with an ominous prognosis and significant morbidity. Surgery remains the treatment of choice but total resection can be achieved in a minority of patients in our center.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more