Endocrine Abstracts

Nuclear hormone receptors (NHRs) are a large family of ligand-activated transcription factors that regulate programs of cellular growth, differentiation and homeostasis. The structurally conserved ligand binding domains (LBDs) of NHRs bind to hydrophobic small molecules including steroid hormones, fat soluble vitamins and bile acids, thereby interpreting small molecule cues to affect transcriptional readouts.The temporal correspondence between metabolic ...

Dr. Ronald M Evans is known for his discoveries and characterization of nuclear hormone receptors, the establishment of the nuclear receptor super family and the elucidation of their universal mechanism of action, this revealed how receptor activation by lipophilic hormones and drugs are transformed into physiology and the treatment of disease.Dr R M Evans obtained his BA and PhD from the University of California, Los Angeles, School of Medicine in 1970 ...