ea0031pl7 | Clinical Endocrinology Trust Lecture | SFEBES2013
Lightman Stafford
The circadian variation of hypothalamo-pituitary-adrenal (HPA) activity is well recognised, with levels of glucocorticoid rising in anticipation of the activity of the coming day (in humans) or night (in rodents). Less well recognised however, is that in common with many other hormones, both ACTH and corticosteroids are released in a pulsatile pattern with the largest pulses occurring in the morning in man explaining the large range of normal morning ...