Endocrine Abstracts

In recent years, the increasing availability of massive computational capacity has reached what may be seen as a ‘tipping point’, bringing once unimaginable computational power into the lab. This is enabling models to be built, fit and refined during experiments, making predictive models that are powerful tools for hypothesis generation and testing. Neuroendocrine systems are at the forefront of these advances. Because of the exceptional opportunities that they offer...

PTSD is an anxiety disorder that occurs among persons exposed to a traumatic event involving life threat and injury. This is a co-morbid psychiatric disorder that occurs along with depression. Cortisol, secreted in the adrenal cortex in response to stress, is an informative biomarker that distinguishes anxiety disorders such as major depression and post-traumatic stress disorder (PTSD) from normal subjects. In comparison to normal subjects, hypocortisolemia was observed during...

Abstract unavailable....

In cardiovascular-renal (CVR) pathology, the renin (REN)-angiotensin (A2) system (RAS) is central as key regulator of blood pressure BP (major CVR risk factor), and it is widely targeted by therapeutical agents. CVR regulations are utterly complex: realistic and integrated models are needed. However RAS is absent or crude in existing models: in the most integrative one (Guyton’s model GM), it is restricted to a simple factor acting on resistances and aldosterone: key elem...