BSPED2012 Poster Presentations (1) (66 abstracts)
A prospective study of pubertal growth in children with inflammatory bowel disease
Avril Mason 1 , Salma Malik 1 , Martin McMillan 1 , Jane McNeilly 3 , Jonathan Bishop 2 , Paraic McGrogan 2 , Richard Russell 2 & Faisal Ahmed 1
1Developmental Endocrinology Research Group, University of Glasgow, RHSC Glasgow, Glasgow, UK; 2Department of Paediatric Gastroenterology, RHSC Glasgow, Glasgow, UK; 3Department of Paediatric Biochemistry, RHSC Glasgow, Glasgow, UK.
Background: Puberty is understood to be commonly affected in adolescents with Crohn’s disease (CD) and ulcerative colitis (UC).
Objective: To determine the impact of IBD on pubertal status and pubertal growth.
Methods: Single centre prospective study over 12 months of 45 adolescents (boys, 23) with CD and 18 (boys, 12) with UC with a median age of 13.4 years (10, 16.6). Assessment included details of disease, anthropometry and biochemical markers of growth and puberty at T0 and T12.
Results: Individually, 10/45 (22%) adolescents with CD had one or more parameter affected: 7 had a HtSDS at diagnosis <−2, 6 had HtSDS <−2 at 0 and 12 months. No subjects remained prepubertal beyond the age at which 97% of population would have expected to enter puberty and only two adolescents with CD showed a delay in progression through puberty. In the whole group, HV showed an inverse association with ESR (r,−0.286; P=0.025).
| T0 | T12 | ||||||
| Group | Ht0 SDS | IGF1(0) SDS | IGFBP3(0) SDS | HV (cm/year) | Change Ht SDS | IGF1(12) SDS | IGFBP3(12) SDS |
| CD | −0.14 (−2.6; 2.1) | −0.4 (−5.8; 2.6) | 0.45* (−1.5; 2.7) | 4.8 (0.2; 8.3) | 0.05 (−0.5; 0.6) | −0.93** (−2.3; 0.9) | 1.91** (−1.9; 3.6) |
| UC | 0.25 (−1.8; 2.7) | −0.5 (−2; 1.4) | 0.3 (−1.9; 1.6) | 5.4 (1.4; 8.7) | 0.16 (−0.5; 0.4) | 0.02 (−1.3; 1.0) | 1.3 (−2.0; 2.1) |
| *P<0.001; P<0.0001 as compared to the normal population. | |||||||
At T0 post-pubertal boys with CD had median urinary luteinising hormone:creatinine and follicle stimulating hormone:creatinine ratios that were significantly lower than the healthy population (P=0.01 and P=0.0001).
Conclusion: As a group, disorders of the pubertal growth spurt are more likely to occur in CD. Achieving disease control may be important in attaining normal growth during puberty.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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