ICEECE2012 Symposia Signalling to and from osteoclast (3 abstracts)
Department of Orthopedics Surgery, Johns Hopkins University, Baltimore, Maryland, USA.
Coupling of bone formation subsequent to bone resorption is a fundamental mechanism for sustaining bone density in adults. We have demonstrated that TGFβ1 released from the bone matrix during osteoclastic bone resorption induces the migration of bone marrow mesenchymal stem cells (MSCs). We also found that IGF1 released from bone matrix responsible osteoblast differentiation of MSCs recruited by TGFβ1 during bone remodeling. TGFβ1 released from the bone matrix during osteoclastic bone resorption induces the migration of MSCs, whereas IGF1, also released from the bone matrix stimulates osteoblast differentiation of MSCs for new bone formation.