Endocrine Abstracts

Studies showed an increase of cardiovascular risk (CVR) and reduction of the life expectancy observed in the anterior pituitary insufficiency (API) subjects. The morbimortality would be related to GH deficiency not substituted.

Aim: To seek the frequency of the hypertension and analyse the predictive factors in subjects with API.

A retrospective study relating 55 (47 women, eight men) subjects with API: interrupted pituitarystalk n:6, Sheehan syndrom n:45, non-functioning pituitary adenoma n:4 followed during 10 years and substituted apart from the GH. The average of PAS and PAD were compared with a reference group (n:60:51 women, nine men).

API subjects with HTA (API+) were compared with non-hypertensive subjects (API−)

Results: The average of PAS and PAD were higher than the witness: 120.86 vs 120.23 mmHg (P<0.064); 70.76 vs 70.27 mmHg (P<0.01) for men 120.90 vs 120.60 mmHg (P<0.05); 70.88 vs 70.30 mm Hg (P<0.005) for women.

Hypertension was found in 20% of cases (11/55). Its appeared 8 years after (1–15) diagnosis.

IAPI+ARE OLDER 552.45±3 vs 35.65±2 years P<0.001) and have more important hypercholesterolemia than others (CT=2.27±0.11 vs 1.86±0.08 g/l P< 0.02).

In the other hand we did not found significant difference for family history, BMI (31.02±2.7 vs 22.2±0.81 kg/m P<0.106), triglyceridemia 1.91±0.3 vs 1.39±0.15 g/l P<0.12) glycemia (0.81 vs 0.84 g/l P=0.59 and GH (1.66±0.68 vs 2.17±0.4 mUI/l P<0.52).

Our results joint the literature regarding the frequency of the hypertension, the age and the dyslipidemia as predictive factors, the familiar history, the BMI and the degree of GHD do not seems to be CVR. Its necessary to substituted with growth hormone and to treat the others CVR.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.