Endocrine Abstracts

We estimated androgen status at 111 female patients (pts) with HH before and after hormonal therapy (HT) by estadiol 2 mg+dydrogesterone 10 mg in sequence manner not <12 months. Median age of pts was 28 y.o., mean duration of HH 6.2 year, isolated HH n=56 group 1, HH as a part of hypopituitarism n=55 group 2, 45 healthy women of the same age were included in control group. Total T, SHBG and DHEA-S levels were measured, free T levels were calculated using standard formula. To estimate the quality of life the General Health Questionnaire (GHQ-28) was used.

Initially in both 1 and 2 groups total and free T levels were significantly lower compared to the controls (P<0.05), decrease was more appreciable in group 2 (see Table 1). DHEA-S levels were significantly lower in group 2 but not in group 1 compared with controls. There are some data that estrogen therapy can provoke depression of androgen levels. During HT the total and free T levels did not changed considerably so position had not worsened. DHEA-S levels even increased and the difference was statistically significant in group 2.

Total T levels positively correlated with the quality of sleep (r=0.47; P=0.02), social and physical activities (r=0.54; P=0.000003) and negatively correlated with depression (r=−0.67; P<0.001) and nervousness (r=−0.57; P=0.0001). Free testosterone levels positively correlated with the positive emotional reactions (r=0.33; P=0.04), social and physical activities (r=0.6; P<0.001), quality of sleep (r=0.46; P=0.003) and negatively correlated with depression (r=−0.7; P<0.001) and nervousness (r=−0.6; P<0.001). DHEA-S levels positively correlated with the positive emotional reactions (0.46; P=0.003), social and physical activities (r=0.5; P<0.001), quality of sleep (r=0.45; P=0.003), daily activities (r=0.56, P<0.001) and negatively correlated with depression (r=−0.55; P<0.001) and nervousness (r=−0.45; P=0.004).

Thus, hypogonadotropic hypogonadism is the disease associated androgen deficit with which influences on quaity of life. Hypoandrogenemia is more severe in patients with hypopituitarism

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.