ICEECE2012 Poster Presentations Female Reproduction (99 abstracts)
Frequency of insulin resistance, assessed by the glucose clamp technique, in 132 PCOS women
F. Tosi 2 , D. Di Sarra 1 , F. Zambotti 1 , M. Dall’Alda 1 , M. Donati 1 , R. Moretta 1 , M. Peroni 1 , C. Signori 2 , B. Caruso 2 , G. Spiazzi 2 , C. Bonin 2 , E. Bonora 1, & P. Moghetti 1,
1University of Verona, Verona, Italy; 2Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Introduction: Insulin resistance is a common finding in women with polycystic ovary syndrome (PCOS) and is considered a major aspect in this condition, as it likely plays a role in the pathogenesis of both hyperandrogenism and several metabolic abnormalities, frequently found in these women. Despite its significance, prevalence of insulin resistance in PCOS subjects is still unclear, as it was assessed in small samples and/or by using surrogate parameters of insulin action. Moreover, it remains also unclear whether this is a feature of lean PCOS subjects.
Methods: To address this issue, 132 consecutive PCOS women were submitted to a careful metabolic phenotyping, including a hyperinsulinemic euglycemic clamp, the gold standard for measurement of in vivo insulin sensitivity. Insulin infusion rate in the glucose clamp was 80 mU/m2 per min, to completely suppress endogenous glucose production.
Results: Mean (S.D.) age of PCOS women was 24 (6) year, and BMI 29.6 (8.0) kg/m2. Thirty-four percent of these subjects were lean, 24% overweight and 42% obese. Mean fasting plasma glucose was 87 (10) mg/dl and insulin 17 (12) mU/l. As compared to reference values of insulin-induced glucose utilization during the clamp, 84% of these subjects were insulin resistant. In particular, 61% of PCOS women with a normal weight, 86% of those overweight and 100% of the obese subjects showed an impaired insulin action. The metabolic syndrome, diagnosed according to the ATP-III criteria, was found in 5% of lean, 26% of overweight and 62% of obese patients. Among the specific metabolic abnormalities, the most common was reduction of HDL-cholesterol, found in 56% of subjects. Fifteen percent of these women had abnormal glucose levels, at fasting and/or after oral glucose.
Conclusions: Our findings show that insulin resistance is a very common finding in PCOS women, even in lean subjects.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This work was supported, however funding details unavailable.
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