Endocrine Abstracts

Background: The purpose of this study was to determine the incidence of premature luteinization in patients with polycystic ovary syndrome and compared the main determinants of success in IVF in PCOS patients with and without premature luteinization.

Methods: Retrospective analysis of 180 PCOS women of Chinese Han origin with infertility who underwent controlled ovarian hyperstimulation (COH) with an exogenous gonadotropin/GnRH antagonist protocol. Hormone levels on the hCG day and IVF outcomes were assessed.

Results: The incidence of premature luteinization was 23.3%. Compared with PCOS patients without premature luteinization, PCOS patients with premature luteinization (PL) had a higher number of oocytes retrieved (18.20±6.6 vs 15.08±7.3, P=0.037) and a higher fertilization rate (72.9±1.9 vs 63.1±2.3, P=0.033), but clinical pregnancy rates were no statistical significance (53.3 vs 56.0, P=0.836). Though the implantation rate was higher in no premature luteinization patients, but the difference was not statistically significant (37.7 vs 30.3, P=0.115).

Conclusion: The PCOS patients with premature luteinization had a higher fertilization rate and high number of oocytes retrieved, and the similar implantation rate and clinical PRs as PCOS patients without premature luteinization.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.