ICEECE2012 Poster Presentations Endocrine tumours and neoplasia (112 abstracts)
B-Lymphocyte Stimulator in neuroendocrine tumors: a new prognostic marker?
M. Fabris 1 , E. Tonutti 1 , F. Vescini 1 , N. Blasone 1 , D. Visentini 1 , S. Pizzolitto 1 , G. De Maglio 1 , M. Isola 2 , F. Curcio 1, & F. Grimaldi 1
University of Udine, Udine, Italy.
Aim of the study: To test B-Lymphocyte Stimulator (BLyS) as a new serological marker in the follow-up of patients with neuroendocrine tumors (NET).
Methods: Eighty-one consecutive patients with NET and 56 age and sex-matched controls were enrolled in the study. According to the clinical course, patients were classified in 2 subgroups: evidence of persistent but stable disease or in remission (n=45) and patients with evidence of recurrent disease (progressive patients, n=36). BLyS and Chromogranin A (CgA) serum levels were analyzed by ELISA.
Results: BLyS levels were more elevated in NET patients than in controls (1153±529 pg/ml vs 655±158 pg/ml; P <0.0001) and correlated with tumor differentiation (1058±398 pg/ml in gastroenteric G1 - typical lung vs 1325±640 pg/ml in gastroenteric G2 - atypical lung; P=0.026). Stable/remission patients displayed significant lower BLyS levels than patients with recurrent disease (889±251 pg/ml versus 1461±623 pg/ml; P <0.0001). BLyS levels did not change in patients who remained stable after 6.6±2.8 months (from 864±283 pg/ml to 809±235 pg/ml; P=ns), while further increased in patients with disease progression (from 1575±810 pg/ml to 1887±1163 pg/ml; P=0.045). CgA, instead, showed inconsistent changes. Metastatic patients displayed higher BLyS levels than non metastatic (1391±724 pg/ml vs 1079±422 pg/ml; P=0.022).
Conclusion: Elevated BLyS levels characterize more aggressive NET patients. BLyS appears as a new potential prognostic marker in the follow-up.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.
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Endocrine Abstracts
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