ICEECE2012 Poster Presentations Endocrine Disruptors (26 abstracts)
The effects of BPA exposure on fat mass and serum leptin concentrations have no impact on bone mineral densities in non-obese premenopausal women.
J. Liu , H. Zhao , Y. Bi , L. Ma , L. Zhang , L. Zhao , B. Tao , L. Sun , T. Wang , Y. Zhao , W. Wang , M. Xu , J. Chen & G. Ning
Rui-jin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai, China.
Objective: Bisphenol A (BPA) exposure may promote obesity, but its effect on bone mineral density (BMD) has not been reported in humans. In the present study, we aimed to examine the complex interplay between BPA exposure, fat mass, fat-free mass, serum estradiol, leptin, osteocalcin levels and BMDs in a group of premenopausal women.
Methods: A total of 246 Chinese premenopausal women aged 20 years and older with regular menstrual cycles were investigated. Body mass index (BMI), fat mass, fat-free mass and BMDs were measured by DXA. Serum estradiol, leptin, osteocalcin, urinary BPA and NTx levels were also tested.
Results: Urinary BPA levels were positively associated with fat mass (r=0.193, P=0.006) and leptin (r=0.236, P=0.001) but not with fat-free mass after adjusting for age and BMI. A multivariate stepwise regression analysis confirmed the positive association between BPA and leptin (β=0.31, P<0.001). Serum leptin levels were positively influenced by fat mass (β=0.746, P<0.001) and BPA (β=0.127, P=0.01) but negatively correlated with fat-free mass (β=−0.196, P<0.001). The changes of BMDs at the lumbar-spine (β=0.298, P<0.001) and femoral neck (β=0.305, P<0.001) were primarily explained by fat-free mass. BPA was not associated with either serum estradiol levels or BMDs. BPA was unrelated to the bone resorption marker, NTx, or the bone formation marker, osteocalcin.
Conclusions: BPA’s effect on fat mass was mediated by leptin. The neutral effect of BPA on BMDs in premenopausal women is due to the exclusive role of fat-free mass, which is unrelated to BPA, rather than of fat mass or leptin in determining BMDs.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This work was supported, however funding details unavailable.
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Endocrine Abstracts
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