Endocrine Abstracts

The study was aimed to compare the outcome of pregnancies in women with type 1 diabetes treated with continuous subcutaneous insulin infusion pump (CSII) or multiple insulin injections (MDI). Total 14 patients were treated with insulin pump and 20 patients were treated with multiple injections; were mainly investigated for HbA1c, incidence of hypoglycemia, fetal outcome, rates of pregnancy induced hypertension and cesarean section. HbA1c with insulin pump was significantly better from that obtained with multiple injections. Hypoglycemic events were significantly less in CSII group as compared to MDI group. Moreover, severe hypoglycemia was not seen in CSII group, whereas there were numerous episodes of severe hypoglycemia in MDI group, few of them required hospitalization. Rate of early or mid pregnancy abortion was 10% treated with multiple insulin injections, while no abortion was seen in CSII group. Fetal prognosis was also better in pump treated patients, macrosomia was seen in 4 new borns in pump group whereas 12 in MDI group. The occurrence of pregnancy induced hypertension was similar in both groups. The rate of cesarean section was not influenced by therapeutic device, similar in both groups.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.