Endocrine Abstracts

The aim was to evaluate the space of hyperhomocysteinemia presence with depression and diabetic nephropathy (DN) in diabetic mellitus type 1 (DMT1) patients.

Materials and methods: it was examined 147 patients with DMT1 (57.1% of males, 42.9% - females) and duration of disease was 11.17 [9.07;12.26] years. Moderate age was 40.08 [30.44; 48.79] years. DN of 3–5 stages was diagnosed in 43 patients (29.3%). To provide analysis it used blood serum creatinine level, total cholesterol (TC) and homocysteine (HC) determining. The hospital scale of anxiety and depression was used for detection of depression.

Results: HC level in DMT1 patients with depression was 10.50 mmol/l vs 9.95 mmol/l in the the patients without depression (U=1066.0; P=0.085). HC level correlated with duration of disease in DMT1 patients (r=0.44; P=0.02).

HC level was 11.20 [8.80;11.65] mmol/l at the presence of DN vs 9.41 [7.96;11.30] mmol/l at the patients without DN (U=605.00; P=0.034). Creatinine concentration was higher at DN presence 81.50 [72.50;86.5] mmol/l vs 76.00 [69.00;83.00] mmol/l at the patients without DN (U=614.50; P=0.004). TC level was 5.60 [4.40;6.60]mmol/l at the patients with DN vs 4.70 [4.00;5.60]mmol/l at the patients without it (U=582.00;P=0.002).

Using quartile value of HC level it was pointed, that creatinine blood level was decreased at the patients with HC level less than 8.35 mmol/l. Analyzing the frequency of DMT1 complications we estimated higher frequency of DN complicated by arterial hypertension (χ2=3.78; P<0.05) in group of patients with HC level more than 12.55 mmol/l to compare the patients with HC level presented less than 8.35 mmol/l.

Conclusion: Increasing DMT1 duration leads to increasing of blood HC level. HC level got the tendency to growing in the patients with D1TM and depression.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.