Endocrine Abstracts

Aim: Few studies demonstrated that self-reported nocturnal sleep duration (NSD) were related with urinary protein excretion. However no previous study has specifically addressed the relationship between 24-hour urinary albumin excretion (UAE) and 24-hour urinary protein excretion (UPE) in newly diagnosed type 2 diabetic patients.

Methods: All patients underwent history taking, physical examination, blood pressure (BP) measurement, 12 lead electrocardiographic evaluation, routine urine analysis, biochemical analysis, 24-hour urine collection to measure UAE, UPE and creatinine clearance. Self reported NSD and daytime sleepiness (using Epworth Sleepiness Scale (ESS)) were recorded for all patients.

Results: In total 110 patients (56 male, 54 female) were included. The average 24-hour UPE, and UAE were 370.4±571.6 mg/day and 162.8±250.5 mg/day respectively. The self reported sleep duration was 7.17±1.07 hours. The mean ESS score was 5.59±2.48. Stepwise linear regression of independent factors including age, gender, smoking status, body mass index, clinical SB and diastolic BP fasting blood glucose, Hba1c, creatinine clearance, insulin resistance as evaluated by HOMA-Index, self reported NSD and ESS score revealed that logarithmically converted 24-hour UAE was related with clinical systolic BP (b:0.012, CI:0.004–0.021, P: 0.005), Hba1c (b:0.097, CI:0.011–0.183, P: 0.027), self reported NSD (b:-0.114, CI:-0.0253 (-)-0.036, P:0.009) and ESS score (b:0.049, CI:0.001–0.096, P: 0.044). Using the same independent parameters 24-hour UPE was related with clinical systolic BP (b:0.01, CI:0.002–0.018, P: 0.011) and self reported nocturnal sleep duration (b:-0.167, CI:-0.0267 (-)-0.067, P: 0.001).

Conclusion: Self reported NSD and daytime sleepiness were related with both UAE and UPE in newly diagnosed type 2 diabetic patients.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.