ICEECE2012 Poster Presentations Diabetes (248 abstracts)
The impact of hyperinsulinemia on the serum IL12p40 subunit concentration
A Nikolajuk 1, , A Adamska 1 , M Karczewska-Kupczewska 1 , N Matulewicz 1 , M Zielinska 1 , M Górska 1 , I Kowalska 1 & M Straczkowski 1,
1Medical University, Bialystok, Poland; 2Polish Academy of Sciences, Bialystok, Poland.
Introduction: Numerous studies indicate an association between low-grade chronic inflammation and predisposition to type 2 diabetes and atherosclerosis. IL12 is a proinflammatory cytokine with proatherogenic properties. IL12 is a disulfide-linked, 70 kDa (p70) heterodimeric glycoprotein composed of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. Many data reported higher levels of p40 subunit than total IL12. The aim of the present study was to investigate the influence of hyperinsulinemia on serum p40 subunit.
Methods: Our study involved 35 young (age: 24.31±2.81 years), apparently healthy men with normal glucose tolerance. Anthropometric measurements, blood biochemical analysis and euglycemic hyperinsulinemic clamp were performed in the studied group.
Results: The serum concentrations of p40 was significantly lower after the clamp than the baseline state (P<0.05). The change in IL12p40 during the clamp was already to the steady-state insulin (SSI) concentrations (r=0.35, P=0.037) – the higher SSI the greater decrease in serum IL12/p40. We found inverse correlations between post-clamp serum p40 and total cholesterol and LDL-cholesterol (r=−0.34, P=0.049 and r=−0.46, P=0.006 respectively). A significant association between basal and post-clamp p40 subunit and lymphocyte cell count (r=0.35, P=0.037 and r=0.45, P=0.006 respectively) and significant negative correlations with neutrophile cell count (r=−0.41, P=0.014 and r=−0.51, P=0.002 respectively) was observed in the studied group.
Conclusion: Our data indicated that hyperinsulinemia decreased serum IL12/p40 concentration.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This work was supported, however funding details unavailable.
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Endocrine Abstracts
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