Endocrine Abstracts

Background and aims: The aim was to determine psychoemotional state in diabetic and non-diabetic patients with or without fractures and its correlation with bone condition.

Materials and methods: We examined 62 postmenopausal women with type 2 diabetes mellitus (DM), 29 of them had bone fracture within last month. The control group included 56 non-diabetic women, 26 within a group were recently fractured. Groups were comparable in body mass index, age, duration of menopause. Diabetic subgroups were comparable in glycosylated hemoglobin level. We measured depressive symptoms using the Beck depression inventory, Zung Self-Rating Depression and Center for Epidemiological Studies Depression Scales. There were also analyzed correlation with lifestyle factors, data of bone densitometry (lumbar spine and femur) and vitamin D level.

Results: As expected in patients with DM frequency of depression were significantly higher compared to women without DM (P=0.01–0.04). There were no rising of depression rate in groups with fracture. The direct correlation between Zung Scale total score and diabetes duration (R=0.513) was found. Only in non-diabetic group there were inverse correlations of depression score with both bone mineral density (R=−0.50 to −0.62) and lifetime weight gain (R=-0.44). In this (non-diabetic) group there were also found direct relationship of depression symptoms with coffee consumption (R=0.43–0.54) and smoking intensity (R=0.46). No correlation of vitamin D level and depression score was detected.

Conclusion: Depression is more common in diabetic women. Frequency of depression among patients with fracture was the same or even a bit lower. Depression was associated with low bone mineral density only in non-diabetic group.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.