Endocrine Abstracts

Objective: To determine the progression rate to impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes (DM2) in normal glucose tolerant (NGT) people during 8 years follow up using WHO 1999 criteria and new criteria (IFG-fasting glucose 5.6–6.9 mmol/l).

Research design and methods: This is an eight year prospective study in a randomly selected urban population aged >=40 years living in Krakow, Poland. 1752 persons had NGT.based on WHO 1999 criteria, 564 of them (32.2% of invited, (209 men and 355 women, aged 60.7, S.D.=9.2) attended the follow-up assessment. Subjects underwent a physical examination including weight/height, waist circumference, biochemical examination including glucose, insulin in 0’, 120’ OGTT and questionnaire examination concerning CVD health history and family history of type 2 diabetes.

Results: The prevalence of DM2, IFG and IGT according to WHO 1999 criteria in examined population with baseline NGT was 4.43%, 3.37% and 9.93% respectively. The prevalence of IFG using new criteria, was 13.48%. Lowering cutoff point for IFG caused 10.11% increase in the prevalence of IFG.

Among people with diagnosed diabetes, 56% had newly diagnosed diabetes during the control study, in 44% participants diabetes was diagnosed in the period between the baseline and control study.

The prevalence of DM2 and IGT/IFG was increasing with increasing age and BMI categories (P<0.05). The lowest obesity prevalence both baseline and after follow up was found in those who remained NGT.

Conclusion: In the studied baseline NGT population after 8 years of follow up high progression rate to impaired glucose metabolism was found. The implementation of new IFG diagnostic criteria increased the prevalence of IFG by 10.1%. The prevalence of impaired glucose metabolism was increasing with age and BMI categories. The lowest obesity prevalence both baseline and after follow up is found in those who remains NGT. Therefore prevention of diabetes initiatives should focus on normal body weight preservation.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This work was supported, however funding details unavailable.